"It's important if somebody does start experiencing some new symptoms of any kind on these medications, we have to remember we don't have very long-term data on these meds, so there are still a lot of unknown risks with these medications," Parrella said
The drug-treated (DT) depression patient group included patients who received drug treatment including antidepressants for the treatment of depression, and the non-drug treated (NDT) group included patients who did not receive drug treatment
Moreover, GLP-1 receptor agonists slow gastric emptyingthe pace at which food leaves your stomach
GLP-1 receptor agonists are a class of FDA-approved medications that mimic this hormone, producing three powerful effects: Appetite suppression signals your brain that youre full sooner and for longer Slowed gastric emptying food moves through your stomach more slowly, reducing hunger spikes Blood sugar regulation stimulates insulin release in response to meals, supporting metabolic health Originally developed for type 2 diabetes management, GLP-1 medications have since been FDA-approved specifically for chronic weight management in adults with obesity or overweight and related health conditions
exendin-4 was relatively small but reproducible
Scientists have not given up on the drugs for these conditions, but they will need to pivot, focusing on new GLP-1 research questions spurred by the trials results